A Multimodal Multiple Kernel Learning Approach To Alzheimer's Disease Detection
Michele Donini, Istituto Italiano di Tecnologia
Joćo M. Monteiro, University College London
Massimiliano Pontil, Istituto Italiano di Tecnologia
John Shawe-Taylor, University College London
Janaina Mourao-Miranda, University College London

Abstract:
In neuroimaging-based diagnostic problems, the combination of different sources of information as MR images and clinical data is a challenging task. Their simple combination usually does not provides an improvement if compared with using the best source alone. In this paper, we deal with the well known Alzheimer"s Disease Neuroimaging Initiative (ADNI) dataset tackling the AD versus Control task. We use a recently proposed multiple kernel learning approach, called EasyMKL, to combine a huge amount of basic kernels in synergy with a feature selection methodology, pursuing an optimal and sparse solution to facilitate interpretability. Our new approach, called EasyMKLFS, outperforms baselines (e.g. SVM) and state-of-the-art methods as recursive feature elimination and SimpleMKL.